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There is a high unmet need for central nervous system (CNS) diseases in the growing aging population. Chronic inflammation is associated with a broad spectrum of neurodegenerative diseases related to aging. Genervon is bringing GM6, a new clinical-stage drug asset, to regulatory approval and commercialization in China for CNS diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), and other neurodegenerative diseases. Most clinical trials for drugs developed through the traditional single-target drug approach have failed to treat the complex neurological disorders that involve multiple interrelated pathways.

GM6 is an innovative first-in-class regulator peptide drug in clinical stage. Genervon Biopharmaceuticals discovered an endogenous embryonic-stage regulator, Motoneuronotrophic Factor (MNTF), and developed from it the pleiotropic drug GM6. GM6 is neither an antibody nor a single-target agonist or antagonist. It is a multi-target regulator which simultaneously acts upon multiple extracellular receptors to modulate a series of signaling pathways mediating inflammation and pro-survival responses in both CNS and immune system. Genervon has validated GM6’s target engagement of multiple targets and druggability. GM6 has been de-risked for toxicity in animal studies and safety in three clinical trials. IND documents filed with the FDA can be used to support regulatory filing in China for clinical trials. Genervon is interested to partner through licensing or merger and acquisition. A complete CMC package is ready for technology transfer.

A clinical-stage US pharma company with a P2B asset (US FDA IND) targeted for multiple substance use disorders and stressor-related disorders (e.g., PTSD) with unmet medical needs.

The everbeat platform is being offered by Grektek, whose mission is to help dramatically improve cardiac care. We created everbeat to improve our ability to take care of ourselves, especially as we get older, and with a strong focus on heart health. Most existing solutions related to cardiac care are unattractive and cumbersome, and brand the patient as weak or sickly. At Grektek, we designed everbeat to be elegant and simple, allowing patients to take better care of themselves with dignity and comfort. We also believe that patients will enjoy the everbeat solution, which means they will use it consistently for a long time – and sustained use of a cardiac monitoring platform is essential to getting healthy.