ImmunoBiochem Canada

ImmunoBiochem is an immuno-oncology biopharmaceutical company that has developed a disruptive approach to targeting unique proteins amplified in cancer secretomes. These targets are secreted from cancer cells and accumulate in tumors, but not in normal tissues, and are constantly recycled in the tumor microenvironment. This novel approach enables the selective and efficacious delivery of immunomodulatory and chemotherapeutic payloads into relevant subsets of cells within the tumor microenvironment, including tumor cells, immune cells and tumor-supporting stroma.
ImmunoBiochem’s IMB-213I candidate delivers a potent innate immune system agonist for the treatment of highly heterogeneous solid tumors, such as TNBC, pancreatic and ovarian cancers.
ImmunoBiochem's IMB-212 candidate delivers a potent cytotoxic payload into difficult-to-treat solid tumors, particularly where no suitable surface targets and no biologics are available.
Company Size (Fulltime employees)
Please specify your partnering goal
Opportunities for collaborations and joint development
Headquartner in China
Assets Information 1
IMB-213I|Novel Immunomodulatory Antibody Conjugate|Solid Tumors|
Assets Information 2
IMB-212|ADC against a novel cancer secretome-based target|Solid Tumors|
Biotech/Pharma Asset Stage
Dr. Anton Neschadim
CEO 
Functionality

Incuron, Inc. United States

Incuron is a private clinical-stage company that develops a novel class of synthetic small molecules, Curaxins, with a unique multi-targeted mechanism of antitumor activity. These chromatin damaging agents interfere with histone/DNA binding causing decondensation of chromatin in tumor cells, functional inactivation of histone chaperone FACT, and simultaneous effect on a set of universal previously undruggable targets, leading to inhibition of pro-cancer transcriptional factors, MYC, NF-kB, HIF1a, and HSF-1, and activation of the tumor suppressor p53, as well as induction of type I interferon response.
Key advantages of curaxins based on current preclinical and early clinical data include:
- novel mechanism of action that would bring the additional treatment option for advanced and relapsed tumors, as well as potential to overcome resistance to previous treatments;
- favorable pharmacology and manageable safety profiles;
- low potential for serious drug-drug interactions providing opportunities for combinatorial therapeutic regimens;
- broad activity in different tumor types that may open wider market opportunities;
- focused phase 2 clinical study program can establish faster clinical proof of concept and build toward accelerated regulatory approval.
Incuron owns a worldwide patent portfolio, including the composition of matter and therapeutic uses of the compounds.

Website:
incuron.com
Headquartner in China
Assets Information 1
The clinical lead curaxin CBL0137 demonstrated dose-dependent, nonclinical efficacy in several preclinical adult and pediatric solid and hematological tumor models, and synergistic activity with multiple conventional drugs. Two Phase 1 clinical trials of CBL0137 in advanced solid tumors (oral and IV formulations) were completed with the results presented at the 2020 ASCO Virtual Annual Meeting (Poster 313 (abstract 3583) and Poster 337 (abstract 3607)). CBL0137 demonstrated favorable pharmacology, a manageable safety profile, and preliminary evidence of antitumor activity with protracted stable disease. It was also studied in patients with hematologic malignancies. Additionally, a Phase I clinical trial of intra-arterial administration to patients with sarcoma or melanoma of extremities is ongoing (NCT03727789). A clinical program in pediatric oncology iscurrently under development. CBL0137 crosses the blood-brain barrier, supporting potential utility in CNS tumors.
Biotech/Pharma Asset Stage
Kristina Zakurdaeva
CEO 
Functionality

Innovate Calgary Canada

University of Calgary based accelerator
Company Size (Fulltime employees)
Year of foundation
2019
Please specify your partnering goal
looking for partners who are interested in investing/assessing discovery stage technologies, and potentially can partner with our accelerator as CSO
Headquartner in China
Assets Information 1
||neuropathic pain|US, UK, CA, DE, FR
Biotech/Pharma Asset Stage
Dr. Morgan Guo
IPM 
Functionality

Innovation Centre Denmark Shanghai China

Partnership between Ministry of Foreign Affair and Ministry of Higher Education and Science of Denmark. Help danish high-tech companies and research instututes to enter Chinese market and find Chinese collaborators
昱 祁
创新合作官员 

Innovation Forum United Kingdom

The Innovation Forum is an accelerator for healthcare ventures. It is supported by a global grassroots network of over 10,000 innovators who seek to improve human health and wellbeing by translating cutting-edge science into innovative products and services. We focus on the future and the evolution of today’s technologies, which range from the nascent stage to the cusp of commercial application.
Company Size (Fulltime employees)
Year of foundation
2013
Please specify your partnering goal
Find partners and network
Headquartner in China
Mr. Giammarco Pacifico
Global business development manager 
Functionality

Innovative Drug Research Centre Chongqing China

Company Description
Website:
Website
Partnering Objectives
Headquartner in China
Li Bo
Project officer/Pharmacist 

INOVOTION France

CRO Preclinical
In vivo efficacy evaluation in oncology
Company Size (Fulltime employees)
Year of foundation
2015
Please specify your partnering goal
New customers and partners
Headquartner in China
Mr. Philippe Fornies
Head of Business Development 
Functionality

Insilico Medicine US Inc United States

Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trial outcomes.
Website:
insilico.com
Company Size (Fulltime employees)
Year of foundation
2014
Please specify your partnering goal
Collaborations on NMEs, therapeutic targets, AI-based generative chemistry
Headquartner in China
Dr. Qingsong Zhu
COO 
Functionality

INTERVENN BIOSCIENCES United States

Venn Biosciences innovates cancer diagnostics using Artificial Intelligence (AI) and next-gen mass spectrometry, unlocking glycoproteomics for Biomarker and Target Discovery.
Website:
intervenn.com
Company Size (Fulltime employees)
Year of foundation
2017
Please specify your partnering goal
partnership and clients
Headquartner in China
Your Research Tool and Service name
venn vista
Service Description
tool for biomarker discovery and diagnostic
Mr. FADZ JABAR
VICE PRESIDENT, BUSINESS DEVELOPMENT 
Functionality

InvivoSciences Inc. United States

InvivoSciences, Inc. (IVS) is a preclinical stage biotech company with a team of drug development experts, including Dr. Joseph Schlessinger, who developed various therapies including, a blockbuster drug - Sutent.
With an increasingly aging population with chronic diseases such as diabetes, heart failure is an urgent and critical challenge without an effective solution. There have been no successful phase III trials in worsening chronic heart failure or heart failure with preserved ejection fraction (HFpEF). Large clinical trials required for the heart failure trials have been the bottleneck. There is clear evidence showing that genetic factors drive heart failure development. Our mission is to cure heart failure one gene at a time.
We have leveraged our advanced artificial intelligence integrated breakthrough in precision medicine discovery platform using patient-derived human micro heart on a chip, NuHeart™, to identify and validate multiple drug pipelines rapidly as well as help us to determine biomarkers and stratify the patients for a clinical trial recruitments. Our precision heart failure pipelines are at least ten times more cost-effective to develop, especially during their clinical stages. Using our platform, we have developed two pipelines of small-molecule candidates for difficult to treat, genetically defined heart failure conditions. Our Pipelines of precision medicines have the potential to deliver better outcomes for patients fighting hard to treat heritable heart disease.
Collaborative patient-driven precision medicine-based drug development empowered with our novel platform will lead to meaningfully better outcomes for heart failure patients, which we refer to as InvivoSciences’ discovery engine to develop target therapies. Our lead program includes candidates in preclinical development for monogenetic heart failures. To date, IVS raised $8.5 Million non-dilutive funding from founders, board, commercial contracts, and grants. The funds have been used to create a portfolio of assets (breakthrough discovery platform, NuHeart™, three genetically defined disease models, current discovery programs, and a strong portfolio of patents including both US and international.
To join and support our drug discovery programs forward, InvivoSciences is seeking world-class life science investors and strategic partners for our Series A round for growth capital for $10 M in two trunches for commercial growth and accelerating our drug program.
Company Size (Fulltime employees)
Year of foundation
2001
Headquartner in China
Ayla Annac
CEO 
Functionality