Maculus Therapeutics United States

Company:
Maculus Therapeutix is a preclinical-stage biopharmaceutical company focused on finding practical solutions to treat chronic diseases of the retina and optic nerve such as wetAMD (Age related Macular Degeneration) in the Ophthalmology space with a novel tunable biodegradable proprietary product – MacuBloc™ capable of delivering any FDA approved drugs for Wet AMD to the site of the disease. With its unique suitability for targeted and extended delivery of drugs to back of the human eyes, MacuBloc™ offers significant benefits to Wet AMD patients over existing products: a single intravitreal injection that lasts an year instead of the current 10-12 monthly injections plus significant potential reduction in inflammation, infection, doctor visits and total cost of care compared to current practice.

Market:
The global market size of Age-Related Macular Degeneration (AMD) is currently $7.7B, growing at 7.6% CAGR and is expected to reach a value of $11B by 2025. Current standard of care involves 10-12 monthly injections with a 30 gauge syringe needle going through the eye sclera, often resulting post-injection pain and possible infection due to repeated injections in a small area as well as ruptured blood vessels in the sclera. By reducing the number of injections from 10+ to just ONE, MacuBloc™ formulation is likely to be a treatment of choice.
Year of foundation
2017
Partnering Objectives
Headquartner in China
Assets Information 1
MacuBloc™ is a tunable, biodegradable, proprietary formulation capable of delivering any FDA approved drugs for Wet AMD to the site of the disease. With its unique suitability for targeted and extended delivery of drugs to back of the human eyes, MacuBloc™ offers significant benefits to Wet AMD patients over existing products: a single intravitreal injection that lasts an year instead of the current 10-12 monthly injections plus significant potential reduction in inflammation, infection, doctor visits and total cost of care compared to current practice.
Biotech/Pharma Asset Stage
Mr Syed Askari, PhD.
Founder & CEO 
Functionality

MedGene Therapeutics United States

MEDGENE is a T cell therapy biotech start-up (late pre-clinical stage) based in Maryland, USA.
- Focused on developing PD1+ peripheral blood-derived, tumor-reactive CD8+ T cell (PBTL) therapies as a platform for the treatment of solid tumors that are rare, orphan, and have critical (high) unmet need
- PBTL is a simpler, smarter version of TIL
- PBTL is a process to select highly tumor-reactive T cells from a patient's peripheral blood based on the expression of two specific T cell surface markers: PD-1 and/or TIM-3
- After selection, expanded to large quantities, it gets re-infused into the patient via the ACT regimen
- PBTL technology has been patented (issued) already in the US, China, the EU, Japan, Australia
- MEDGENE has robust Clinical Development Pipelines (currently, 9 as monotherapy way)
- Looking for funding for entering Phase I/2 in three pipelines in the US
- Looking for partnering for the Asian market (China, Japan, South Korea)
Website:
www.medgene.us
Company Size (Fulltime employees)
Partnering Objectives
Please specify your partnering goal
Seed (Pre series A) Fundraising of 2M USD/ Partnering in China
Headquartner in China
Biotech/Pharma Category
Biotech/Pharma Asset Stage
Yong H. Park
CEO 
Functionality

Medical/Legal Genetics inc United States

A CAP, CLIA And AABB certified clinical lab specialized in genetic and molecular diagnosis
Website:
1800dnagenes.com
Company Size (Fulltime employees)
Year of foundation
1958
Please specify your partnering goal
Similar field
Headquartner in China
Biotech/Pharma Category
Medtech Category
Dr. Helen Hua
MD, MS, MT(ASCP) 
Functionality

Micar Innovation (Micar21) Bulgaria

Micar Innovation is a drug discovery factory. The company has found a niche where it is able to create a large societal impact by improving the quality of life through discovery novel blockbuster drug molecules for a large class of diseases (Pipeline). Micar Innovation focuses on entire drug discovery process using improved structure based insilico drug design from scratch till Preclinical phase with advanced predictions of activity, selectivity and ADMET.

Company Size (Fulltime employees)
Year of foundation
2016
Please specify your partnering goal
Drug Discovery Collaborations
Headquartner in China
Biotech/Pharma Asset Stage
Slides Deck
(pdf, 939.67KB)
Mr. DIMITAR DIMITROV
LinkedIn logo CEO 
Functionality

Mito Biopharma United States

Mitochondria play a central role in metabolic diseases and cancer. Targeting mitochondria for therapeutic development provides a unique opportunity for the effective treatment of these devastating diseases, including nonalcoholic steatohepatitis (NASH), type 2 diabetes (T2D), and various cancers.

Mito Biopharma is a leading company in designing safe chemical mitochondrial uncouplers for
therapeutic development. We have developed a transformative and proven platform technology supporting lead development. Proof-of-concept studies demonstrated broad applications of the platform and superiority of mechanism of action. Therapeutic leads are protected by strong IP protection (worldwide composition-of-matter patent protection). The technology impacts high-value markets including NASH/T2D, Covid-19, and cancer.

We have IND- leads for NASH/T2D, Covid-19, and liver metastatic cancer. Our current focus is on a NASH lead. The company is seeking resources to support the NASH lead for IND and Phase I development, as well as pipeline development.
Company Size (Fulltime employees)
Year of foundation
2012
Please specify your partnering goal
Development of a drug lead to clinical stage
Headquartner in China
Assets Information 1
MB-W53A|Small molecule NASH IND Lead|NASH|
Assets Information 2
WB-W53B|Small molecule Covid IND lead|Covid-19|
Biotech/Pharma Asset Stage
Dr. "Victor" Shengkan Jin
Founder and CEO 
Functionality

NeoProgen United States

Cardiac Focused Stem Cell /Secretome Exosome company . Immortalized cell line
Company Size (Fulltime employees)
Year of foundation
2018
Please specify your partnering goal
Out license Assets
Headquartner in China
Assets Information 1
Neo3002|Immortalized cell line|Heart Failure / AKI|None yet
Biotech/Pharma Asset Stage
Mr. Bill Niland
CEO 
Functionality

OncoMyx Therapeutics United States

OncoMyx Therapeutics is developing potentially best-in-class (multi-armed, IV/systemically-delivered, precision medicine) oncolytic immunotherapies based upon the myxoma virus (MYXV) platform, and we have demonstrated mechanism of action and combinatorial efficacy (tumor growth inhibition) when dosed IV with various checkpoint inhibitors in multiple animal models. Our company has the industry’s most experienced oncolytic virus (OV) development team and an experienced SAB, and CEO Steve Potts was previously an executive at Ignyta (acquired by Roche for $1.7B). OncoMyx raised a $25M series A in June 2019 to advance our lead preclinical program to IND, and among our investors are BIVF (exited OV investment ViraTx for $244M at preclinical stage in 2018) and Jonathan Lim (Ignyta CEO & current Erasca CEO). On the heels of presenting our preclinical data at SITC and announcing the appointment of Mirati CEO Chuck Baum as our new Chairperson, OncoMyx is seeking a $50M+ series B/crossover to prepare for an IPO and focus on a future transition into a clinical-stage organization. Pasted below are links to our SITC posters and some recent Fierce and BioSpace articles focused on our company.

https://www.oncomyx.com/oncomyx-announces-presentation-of-preclinical-efficacy-data-of-novel-oncolytic-immunotherapy-at-sitc-2020/
https://www.fiercebiotech.com/research/arming-rabbit-pox-virus-to-fight-cancer
https://www.biospace.com/article/oncomyx-s-oncolytic-virus-platform-shows-preclinical-efficacy-boosting-immunotherapy-potential/

Company Size (Fulltime employees)
Year of foundation
2018
Partnering Objectives
Please specify your partnering goal
Fundraising and Licensing-out
Headquartner in China
Biotech/Pharma Asset Stage
Slides Deck
(pdf, 2.38MB)
Dr. Steven Potts
Cofounder, CEO & Director 
Mr. Michael Wood
Cofounder, COO & CFO 
Functionality
Dr. Leslie Sharp
Chief Scientific Officer 

Phyteau United States

Phyteau is developing an innovative, new class of therapeutics for diabetes, obesity, related conditions like NAFLD, NASH and prediabetes, and weight-loss. Unlike many drugs in the market today, our therapeutics are completely safe, and free of adverse side-effects.

Phyteau’s new incretin-based approach activates the body’s natural metabolic system
by triggering specialized enteroendocrine cells in the lining of the intestines to release
therapeutic levels of key hormones, including GLP-1, PYY and CCK. These boosted hormones:

1) signal insulin release,
2) reduce blood sugar levels and peaks, and HbA1c,
3) reduce appetite, food intake and weight, increase satiety,
4) slows gastric emptying and intestinal motility,
5) improve metabolism and fat thermogenesis,
6) reduce liver fat and fibrosis,
7) protect against many age-related functional declines and conditions, and
8) provide restorative and protective benefits to the cardiovascular and nervous systems and major organs

The result is safe and affordable first-line treatments that provide a powerful tool for blood sugar control, weight-loss and improving metabolism. Our technology, developed at Caltech, UCLA and Cedars Sinai Medical Center, has 3 patents awarded, 5 more pending, with more planned.

Phyteau’s deep technology platform and portfolio of agents allows us to address growing unmet global needs in a variety of markets. We have 3 pharmaceutical products in development as well as breakthrough medical and functional food products and other consumer health & nutrition products.

Year of foundation
2017
Headquartner in China
Assets Information 1
Phyteau's therapeutic platform represents a comprehensive range of gut hormone secretagogues. Our gut hormone secretagogues are powerful agonists for GCPR's on enteroedocrine cells in the intestines, causing the therapeutic release of metabolic gut hormones (including GLP-1, PYY and CCK).
Biotech/Pharma Asset Stage
Slides Deck
(pdf, 294.95KB)
Bonn Macy
CEO 
Functionality

Pleiogenix United States

Pleiogenix is a clinical-stage bio-pharmaceutical company that will develop safe and effective treatments for liver and other diseases with significant unmet medical needs. The initial disease that Pleiogenix is targeting is alcoholic hepatitis (AH), with additional diseases to follow (COVID-19, Fibrosis, and NASH) . AH is a deadly liver disease resulting in mortality in most patients within 6 months, in the absence of a liver transplant. The global and US prevalence is 20-25%. The AH market is estimated to be $1.2 Billion in 2025, having a current annual growth rate of 6% (2019-2025). There are no approved efficacious therapeutics for the prevention or treatment of AH (dexamethasone reduces inflammation). The target patients for therapy include those with moderate and severe forms of AH. Pleiogenix has identified a Phase 2A-ready drug candidate, PLG888, an orally available, pan-PPAR agonist (non-thiazolidinedione) that increases circulating adiponectin without eliciting body weight gain or edema. Adiponectin is a hormone possessing significant anti-inflammatory, anti-fibrotic, and multiple metabolic clinical benefits. In patients suffering from AH, inflammation is severely increased. In animal models of NASH, increased adiponectin is linked to decreased systemic inflammation, increased hepatic fat oxidation, decreased hepatic fibrosis, and amelioration of NASH. Thus, PLG888 has the potential to become the first prescription pharmaceutical that exhibits multiple beneficial effects, in the context of AH.
Company Size (Fulltime employees)
Year of foundation
2018
Partnering Objectives
Please specify your partnering goal
Fundraising (Seed Round)
Headquartner in China
Assets Information 1
PLG888|Orally-available, Phase 2A-ready drug candidate|alcoholic hepatitis|7 US patents; 1 each for Japan, Great Britain, France, Germany, and Australia
Assets Information 2
PLG888|ailable, Phase 2A-ready drug candidate|COVID-19; prevent /reduce cytokine storm|7 US patents; 1 each for Japan, Great Britain, France, Germany, and Australia
Assets Information 3
PLG888|Orally-available, Phase 2A-ready drug candidate|non-alcoholic steatohepatitis (NASH); Fibrosis diseases|7 US patents; 1 each for Japan, Great Britain, France, Germany, and Australia
Biotech/Pharma Asset Stage
Dr. Joseph Evans
CEO & President 
Functionality

Rancho Santa Fe Bio,Inc. United States

We are a start-up company with a Phase III ready small molecule drug for the treatment of aortic valve stenosis. We

We licensed the drug from the Mayo Clinic and the drug has been part of the NIH's NCAT's Program in which they put in $5 million for our Phase I and Phase II clinical trials and Sanofi put in another $1 million for manufacturing.

We are raising a Series A round now and we welcome interest from Chinese investors and partners.

You can reach me at 858-205-5091.

Thanks.

----Randy Berholtz
Website:
www.rsfbio.com
Company Size (Fulltime employees)
Year of foundation
2019
Please specify your partnering goal
Investment and Chinese partner
Headquartner in China
Biotech/Pharma Category
Assets Information 1
Ataciguat|Small Molecule|Aortic vale stenosis|Worldwide
Biotech/Pharma Asset Stage
Mr. Randy Berholtz
Chairman and CEO